SIGNAL TRANSDUCTION PATHWAYS INVOLVED IN TRANSCRIPTIONAL REGULATION OF TYROSINE HYDROXYLASE

*SUMMARY Motivation: Tyrosine hydroxylase (TH) has been shown to be very intensively regulated on different levels, not only the levels of transcription and translation, but posttranslational modification as well. Theoretical analysis of the pathways involved in regulation of TH expression would allow to understand the mechanisms of development of diseases associated with alterations in TH function such as Parkinson, Alzheimer disease and arterial hypertension. Results: Experimental evidence obtained from experiments of activation of six TH promoter motifs in response to a number of various stimuli in Rattus norvegicus has been analyzed. Based on the facts reviewed in literature a series of diagrams have been created that describe the mechanisms and pathways involved in this regulation. Availability: http://biopath.biouml.org.