Comparison of SN and HI antibody dose response curves in chickens, rabbits, foals and horses following vaccination with equine influenza vaccine

Abstract After vaccination of chickens, rabbits, foals and horses, HI and SN antibody dose response curves were compared for A/Equi 1/Prague and A/Equi 2/Paris strains. The two curves are parallel for a given strain and the relationship of HI and SN titres is constant, whatever the animal species. The distribution of HI and SN titres varies for the two strains. This variation, which is independent of animal species, may be related to the number of sites necessary for the antigenic-antibody response in vitro . It is suggested that the testing of equine influenza vaccine be carried out in the chicken in the light of these results.