Synthesis of lower chain allenic prostaglandins (1)

Abstract The synthesis of four lower chain allenic prostaglandin F α analogues IXA-D is described. The allenyl moiety has only occasionally been incorporated into the prostanoid skeleton and in all the examples thus far reported ·(2,3), this functionality is located in the upper side chain at carbons 4–6. This communication describes the synthesis of four isomeric allenyl PGF α derivatives wherein the cumulated diene system is situated at positions 13–15.