Anticonvulsant activity of 5-bromo-2,4-dichloropyrimidine derivatives: Synthesis and characterization

A series of new 5-bromo-2, 4-dichloropyrimidine derivatives, 3(a-f) were synthesized by using different aryl aldehydes. The synthesized compounds were characterized by FT-IR, 1H NMR, 13C NMR and mass spectral studies. The newly synthesized compounds were screened for their anticonvulsant activity against maximal electroshock seizure (MES) model in male wistar rats and compared with the standard drug phenytoin. The neurotoxic effects were determined by rotorod test by using mice. Compound 3b was found to be most potent of this series. The same compound showed no neurotoxicity at the maximum dose administered (100 mg/kg). The compound 3b showed 68.15% protection in comparison to phenytoin which completely inhibited the convulsions produced by electro-convulsometer, Similarly, compounds 3e and 3a showed moderate protective effects and a significant difference in protectiveness were observed when compared to standard group.