Relationship between inductive effect index and gas phase basicity of aliphatic amine, alcohol and ether

The relationship of gas phase proton affinity (PA) of aliphatic amines, alcohols and ethers, inductive effect index (I) of alkyl group, atomic charge (q(x)), electronegativity of element ( X-N) of affinity atom in RX molecules was studied. The results indicate that PA of aliphatic amines, alcohols and ethers can be quantitatively described as follow: PA (kJ (.) mol(-1)) = 2732.0333 - 2457.1510 Sigma I - 1492.2351q(x) - 732.6277X(N) On the basis of this corelation, the gas phase basicities of 64 aliphatic amines, alcohols and ethers are predicted with average relative error less than or equal to0.34%.