Effect of flavone in roots of kudzu vine on protecting against alcoholic liver injury.

Objective To observe the protective effect of flavone in roots of kudzu vine on rat model of liver injury caused by alcohol. Method Rat models of alcoholic liver were established. The contents of malondialdehyde (MDA), triacylglycerol(TG) and reduced glutathione(GSH) in liver tissue were measured, and the pathological and histological changes of liver were observed. Results The MDA contents in liver tissue in the high, middle, and low dosage groups were 18.6、 18.7、18.4nmol/g respectively, significantly lower than that in the model control group (32.4 nmol/g). The TG contents in liver tissue in the high, middle, and low dosage groups were 2.27、2.74、2.69mmol/100g respectively, significantly lower than that in the model control group (4.97mmol/100g). while the GSH contents in liver tissue in the high, middle, and low dosage groups were 351.2、336.9、360.3μmoL/100g respectly, significantly higher than that in the model control group(276.4μmoL/ 100g). The average value of pathological changes in rat liver in the high, middle, and low dosage groups were 51.4、61.3、 102.6 respectively, significantly lower than that in the model control group (206.6). Conclusion The flavone in roots of kudzu vine has a significant protective effect on liver injury caused by alcohol.