Costello syndrome with decreased glucose tolerance

Since Costello reported two cases in 1971, the syndrome has become an entity. These patients had coarse faces, redundant skin on the hands and feet, curly hair, growth- and psychomotor retardation. Common but not invariable features are nasal polyps and typical facies associated with feeding problems in infancy and a distinctive friendly personality. Cardiomyopathy may occur, other visceral involvement is rare. The natural history evolves [...]