Ecological momentary assessments (EMA) did not improve responsiveness of patient-reported outcomes on quality of life.

Abstract Objective Clinical practice guidelines recommend questionnaires with short recall. We compare responsiveness of ecological momentary assessments (EMA) and retrospective assessments of thyroid-related quality of life. Study Design and Setting Patients with newly diagnosed thyrotoxicosis completed retrospective Thyroid-related Patient-Reported Outcome measures (ThyPRO) with 4-week and 1-week recall, respectively, and three daily EMAs for four weeks at time of inclusion and again after treatment (N=115). Magnitude of change and statistical power (F-test statistics) were compared. Two designs were applied to the same data: Design 1 mimicked the practical realities of clinical trials by comparing 4-week recall ThyPRO administered at time of inclusion with EMA initiated at time of inclusion and collected prospectively for one week, thus not covering the same time frame nor duration. Design 2 compared assessments covering the same 4 weeks following inclusion. Results Design 1: estimated change and statistical power were significantly larger for 4-week ThyPRO compared with EMA. Design 2: retrospective assessments and EMA had comparable change and power. Repeated 1-week ThyPRO administrations increased the statistical power. Conclusion Selecting the optimal time frame for evaluation proved crucial for responsiveness. EMA did not provide higher responsiveness than retrospective measures in either design. Repeated 1-week ThyPRO administrations increased statistical power.