Application of Tamura texture analysis in monitoring HIFU ablation of rabbit VX2 breast tumor

Objective To evaluate Tamura texture parameters in judging the coagulative necrosis of target tissues under the treatment of the high intensity focused ultrasound(HIFU).MethodsTotally 120 New Zealand rabbits were randomly divided into 3 groups according to different irradiation intensities of HIFU for 3 s targeted on the VX2 breast tumors of the rabbits,i.e.90 W group(n=40),120 W group(n=40) and 150 W group(n=40).The ultrasonography obtained before and immediately after irradiation and 3 eigenvalues of Tamura texture parameters(directionality,roughness and contrast) were extracted.By selecting these obtained parameters through a support vector machine,the data were analyzed.ResultsThe sensitivity,specificity and accuracy rate of Tamura texture analyses was 89.71%(61/68),69.23%(36/52) and 80.83%(97/120),of gray was 57.35%(39/68),63.46%(33/52) and 60.00%(72/120).The sensitivity and accuracy rate of the former were higher than those of the latter(both P0.001).The accuracy rate of Tamura texture analyses in 90 W group and 120 W were higher than that of gray [77.50%(31/40) vs 50.00%(20/40),P=0.011;80.00%(32/40) vs 55.00%(22/40),P=0.017].ConclusionWith more advantages than gray evaluation,Tamura texture analysis is applicable for the judgment of coagulative necrosis.