Identification of Salinity Stress Tolerant Proteins in Sorghum Bicolor Computational Approach

Sorghum bicolor is the fifth most important cereal crop in the world after rice, wheat, barley and maize and is grown worldwide in the semi-arid and arid regions. Functional identification of proteins and a detailed study of protein-protein interactions in Sorghum are very essential to understand the biological process underlying the various traits of crops such as salt stress, yield and drought response. The molecular mechanisms that exists among them are still unclear due to the limited studies available in the literature and databases. In this paper, salt stress tolerance responsive protein-protein interaction network has been constructed using STRING database. A comprehensive bioinformatics analysis of this network has been performed using Cytoscape, through the computation of centrality measures and functional enrichment study. This study has resulted in the identification of Sb02g023480.1, Sb01g040040.1, Sb09g027910.1, Sb03g031310.1, Sb10g002460.1 as salt stress tolerant proteins in Sorghum bicolor. However, experimental studies are required to confirm this observation.