Prodigiosin induces apoptosis of B and T cells from B-cell chronic lymphocytic leukemia
2003
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We have previously reported that prodigiosin (2-methyl-3-pentyl-6-methoxyprodigiosene) induces apoptosis in human hematopoietic cancer cell lines with no marked toxicity in nonmalignant cell lines. In this study, we demonstrate that prodigiosin induces apoptosis of B-cell chronic lymphocytic leukemia (B-CLL) cells (n=32 patients). The dose–response for the cytotoxic effect of prodigiosin was analyzed in cells from 12 patients showing an IC50 of 11625 nM. Prodigiosin induced apoptosis of B-CLL cells through caspase activation. We also analyzed the cytotoxic effect of prodigiosin in T cells from B-CLL samples and no differences were observed with respect to leukemia cells. This is the first report showing that prodigiosin induces apoptosis in human primary cancer cells.
Keywords:
apoptosis, B-CLL, caspases, chemotherapy
Keywords:
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