Hypoxia-increased RAGE and P2X7R expression regulates tumor cell invasion through phosphorylation of Erk1/2 and Akt and nuclear translocation of NF-κB

Marco Tafani , Luana Schito, Laura Pellegrini, Lidia Villanova, Gabriella Marfe, Tahira Anwar, Roberta Rosa, Manuela Indelicato, Massimo Fini, Bruna Pucci and Matteo A.Russo Department of Experimental Medicine, Sapienza University, 1, 00161 Rome, Italy, Department of Medicine, Institute of Genetic Medicine, Johns Hopkins University School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA, Department of Experimental Medicine and Biochemical Sciences, University of Rome "Tor Vergata", 00133 Rome, Italy, Department of Biosciences Division of Biochemistry, University of Helsinki, Helsinki 00100 Finland, Department of Molecular and Clinical Endocrinology and Oncology, University of Naples ‘‘Federico II’’, 80138 Naples, Italy and Department of Cellular and Molecular Pathology, IRCCS San Raffaele Pisana, 00163 Rome, Italy