Purification and characterization of porphyromonas gingivalis outer membrane antigens

Abstract Porphyromonas gingivalis is strongly associated with periodontal disease. Significant titres of specific IgG antibodies to P. gingivalis can be found in healthy individuals and those with periodontitis. In this study, 22 outer membrane antigens ranging from 15.5 to 107.6 kDa were recognized by sera from persons with periodontitis and controls. Serum from individuals with periodontitis showed a significantly higher IgG response to a 31.4-kDa antigen ( p p P. gingivalis antigens. The role of these two antigens in the pathogenesis of periodontal disease remains to be determined.