Stability of Cefoxitin Sodium for Injection Mixed with Glucose and Sodium Chloride Potassium Chloride Injection

Objective:To study the stability of cefoxitin sodium for injection mixed with glucose and sodium chloride-potassium chloride injection(GNK) at room temperature(25 ℃).Methods:The mass concentration of cefoxitin was determined by HPLC,the appearance of the solution was observed and its pH value and particles were tested.Results:There were no significant changes in appearance,pH value and mass concentration of the mixed solution within eight hours,and the particles met the pharmacopoeia requirements.Conclusion:Cefoxitin sodium for injection mixed with GNK at room temperature(25 ℃ )was compatible and it should be used within 8 hours.