Aromatic constituents from Ganoderma lucidum and their neuroprotective and anti-inflammatory activities

Abstract Five new aromatic compounds, designed as lucidumins A-D ( 1–4 ) and lucidimine E ( 9 ), along with seven known aromatic compounds ( 5–8 , 10–12 ) were isolated from Ganoderma lucidum . Their structures were determined by spectroscopic method. Bioactive evaluation showed that compounds 2–4 and 6–10 displayed remarkable neuroprotective activities against corticosterone-induced PC12 cell damage, with the cell viability ranging from 69.99% to 126.00%; and compounds 1–4 , 9 and 10 exhibited significant anti-inflammatory activities against LPS-induced nitric oxide (NO) production in RAW264.7 macrophages, with IC 50 values ranging from 4.68 to 15.49 μM. In particular, compound 10 showed remarkable neuroprotection with EC 50 value of 2.49 ± 0.12 μM, and potent anti-inflammation with IC 50 value of 4.68 ± 0.09 μM.