An exposition of 11C and 18F radiotracers synthesis for PET IMAGING.

The development of new radiolabeled Positron emission tomography tracers has been extensively utilized to access the increasing diversity in research process and to facilitate the development in research methodology, clinical usage of drug discovery and patient care. Recent advances in radiochemistry as well as latest techniques in automated radiosynthesizer have encouraged and challenge the radiochemist to produce the routinely developed radiotracers. Various radionuclides like 18F, 11C, 15O, 13N 99mTc, 131I, 124I and 64Cu are used for incorporating into different chemical scaffolds among them 18F and 11C tagged radiotracers are mostly explored such as 11C-Methionine, 11C-Choline, 18FFDG, 18F-FLT, and 18F-FES. This review is focused on the development of radiochemistry routes to synthesized different radiotracers of 11C and 18F for clinical studies.