Effect of incorporating antifungals on the water sorption and solubility of interim resilient liners for denture base relining

Abstract Statement of problem Incorporating antifungals into interim denture resilient liners has been proposed to prolong their clinical longevity and to treat denture stomatitis. However, information is lacking on the effect of this addition on water sorption and solubility. Purpose The purpose of this in vitro study was to evaluate the addition of minimum inhibitory concentrations (MICs) of antifungals for Candida albicans biofilm on the water sorption (WS) and solubility of interim denture resilient liners. Material and methods Disk-shaped specimens (n=10; 50×0.5 mm) of tissue conditioner (Softone) and resilient liner (Trusoft) were created either without (control) or with the incorporation of 1 of the 3 following drugs at MICs (g of drug per g of resilient material powder): nystatin (Ny, 0.032g/g), chlorhexidine diacetate (Chx, 0.064g/g), and ketoconazole (Ke, 0.128g/g). Specimens were dried; immersed in water for 24 hours and 7 or 14 days; weighed, dried, and weighed again. Data (μg/mm 3 ) were analyzed by 3-way ANOVA followed by the Tukey-Kramer honest significant differences test (α=.05). Results At the 14-day interval, only the addition of Chx (483.0 ±61.0 μg/mm 3 ) increased the WS of the tissue conditioner compared with the control group (244.0 ±42.0 μg/mm 3 ; P .001). For all periods, the solubility of both materials increased with the addition of Chx (27.7 ±6.1 μg/mm 3 ) and Ke (30.9 ±5.3 μg/mm 3 ) compared with the control group (22.5 ±6.0 μg/mm 3 ; P .001). Conclusions After 14 days, the addition of Ny and Ke at MICs in both Softone and Trusoft and addition of Chx in Trusoft did not affect WS. The solubility of the 2 interim materials was not altered by the addition of Ny for up to 14 days.