Monitoring of nanoparticle reactivity in solution: interaction of L-lysine and Ru nanoparticles probed by chemical shift perturbation parallels regioselective H/D exchange
2017
Thanks to new water-soluble Ru nanoparticles (NPs) stabilized by sulfonated NHC ligands, we demonstrate that it is possible to monitor the catalyst/substrate interaction using NMR chemical shift perturbations (CSPs), under conditions that closely resemble those applied during the enantiospecific C–H deuteration of L-lysine. Correlating the pH dependence of the interaction of L-lysine with the surface of the RuNPs and its subsequent deuteration, our study underscores the importance of oriented binding to the surface as a critical factor for H/D exchange.
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