Voltammetric assay of methadone in urine

A simple, rapid and sensitive voltammetric method for the determination of methadone in human urine is proposed, which permits the detection of concentrations of methadone as low as 0.3–0.4 µg ml–1. The proposed method was compared with methods normally used in clinical trials, such as the enzyme multiplied immunoassay technique, and was found to be superior with regard to cost and to possess high sensitivity.