Effectiveness and Safety of Oral Misoprostol for Cervical Ripening before Artificial Abortion of First-trimester Pregnancy:A Systematic Review

Objective:To evaluate the effectiveness and safety of oral misoprostol for cervical ripening before artificial abortion of the first-trimester pregnancy.Methods:Related original studies were searched and meta-analysis was conducted later.After heterogeneity test,data were pooled using fixed effect model,sensitivity analysis or randomized effect model,etc.Results:Five original trials (n=688) were found,quality of foreign studies was better than that of Chinese ones.Using oral misoprostol had a higher rate of satisfied cervical ripening when compared with placebo,the blood loss and the incidence of pain in the operation could be decreased;but regarding to the incidences of PAAS,gastrointestinal adverse reaction,abdominal pain after taking drugs and the duration of operation,there were no significant differences.Conclusions:This review showed it was important to improve the quality of Chinese original studies and standardize the outcomes.Taking orally,misoprostol had a satisfied clinical effect for ripening cervix.In other outcomes of effectiveness,the differences were not obvious.The evaluation of the safety need more proves.