SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF SOME SUBSTITUTED PYRAZOLYL AND PYRAZOLINYL-1, 3, 4-THIADIAZINO (6,5-b) INDOLES.

Several N-[{5-(1’-phenyl-5’-(substituted aryl)-2’-pyrazol-3’-yl)amino}-1,3,4-thiadiazol-2yl]methylamino[1,3,4]thiadiazino(6,5-b)indole 8(a-i) and N-[{5-(1’-Acetyl-5’-(substituted aryl)-2’-pyrazolin-3’-yl)amino}-1,3,4-thiadiazol-2-yl] methyl amino[1,3,4]thiadiazino(6,5-b)indole 9(a-i) have been synthesized from N[{(5-(Arylidinylacetyl)amino)-1,3,4-thiadiazol-2-yl}methylamino]-1,3,4-thiadiazino(6,5-b) indole 7(a-i). All the synthesized compounds have been characterized by elemental and spectral (I.R., 1 HNMR, Mass) analysis. Furthermore, above said compounds were evaluated for their antifungal and antibacterial activities. Compound 9c was found the most potent one with lesser toxicity in this series.