Useful thiazole carboxamide and pyridine carboxamide Compound pim kinase inhibitors

Pharmaceutically present disclosure describes the formula (I) thiazole and pyridine carboxamide derivative or a pharmaceutically acceptable salt thereof, compositions and methods of use, wherein: X is C or N; A, B, and D ring; the bond - represents a normalization of bond in the aromatic ring comprising N and X are both in its form when X is C by C = C bond represented when X is N and is represented by a single bond; ring a has the formula ( A-1) or (A-2); wherein E1 and E2 ring. The compounds inhibit the activity of Pim kinases and are therefore useful in the treatment of diseases associated Pim kinase activity, including, for example, cancer and other diseases.