High Throughput Screening of a Catalyst Library for the Asymmetric Transfer Hydrogenation of Heteroaromatic Ketones : Formal Syntheses of (R)-Fluoxetine and (S)-Duloxetine

Elina Buitrago,Helena Lundberg,Hans Andersson,Per Ryberg,Hans Adolfsson

High Throughput Screening of a Catalyst Library for the Asymmetric Transfer Hydrogenation of Heteroaromatic Ketones : Formal Syntheses of (R)-Fluoxetine and (S)-Duloxetine

2012

Elina Buitrago
Helena Lundberg
Hans Andersson
Per Ryberg
Hans Adolfsson

A total of 21 amino acid based ligands including hydroxy amide, thioamide, and hydroxamic acid functionalities, respectively, were combined with [Ru(p-cymene)Cl2]2 and [RhCp*Cl2]2, and used as cata ...

Keywords:

Enantioselective synthesis
Noyori asymmetric hydrogenation
Inorganic chemistry
Organic chemistry
Hydroxamic acid
Catalysis
Transfer hydrogenation
Amino acid
Amide
Thioamide
Chemistry

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