Association between the DRD2 gene Taq1A (C32806T) polymorphism and alcohol consumption in social drinkers

An association between the DRD2 Taq1A (C32806T) polymorphism and social alcohol consumption in the opposite direction to that reported for alcoholism has recently been reported in a male Finnish sample. We attempted to replicate these findings in two independent samples, and extend on previous work by including female participants. The DRD2 A1 allele was significantly associated with reduced alcohol consumption in sample one (P ¼ 0.004) and sample two (P ¼ 0.015). In sample two there was