Differentiation and Characterization of Tr1 Cells.
2016
Regulatory T cell–mediated suppression serves as a pivotal mechanism of negative regulation of immune-mediated inflammation. Type 1 regulatory T cells (Tr1 cells) are an important subset of CD4+ T cells that prevent excessive inflammatory responses and maintain immune tolerance. The anti-inflammatory role of Tr1 cells is mediated in part by their production of interleukin 10 (IL-10), which dampens the function of both antigen-presenting cells and antigen-specific effector T cells. Additionally, Tr1 cells can kill effector and myeloid cells through the perforin-granzyme B pathway. Adoptive transfer of in vitro differentiated Tr1 cells can be used to suppress autoimmune tissue inflammation in vivo. This unit describes the in vitro stimulation of naive murine CD4+ T cells using IL-27 to generate IL-10–producing Tr1 cells. © 2016 by John Wiley & Sons, Inc.
Keywords:
T cell differentiation;
CD4;
IL-27;
Tr1;
IL-10
Keywords:
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