Результаты дифференциальной диагностики и терапии первичной медиастинальной В-крупноклеточной лимфомы

Results of diagnostic work up and treatment of 42 patients admitted to our department from October 2003 to April 2009 with preliminary histological diagnosis of primary mediastinal diffuse large B-cell lymphoma are presented. After review of histological slides and immunohistochemical evaluation of biopsied material the diagnosis of primary mediastinal diffuse large B-cell lymphoma was verified in 36 (86 %) of cases. In the rest of the patients the final diagnoses were as follows: anaplastic large T-cell lymphoma (2), T-cell lymphoblastic lymphoma (1), myeloid sarcoma (1), neuroendocrine cancer (2). The chemotherapy protocols used for treatment of patients with verified diagnosis of primary mediastinal diffuse large B-cell lymphoma were as follows: 17 patients R-CHOD(8)R-EDHAP, 4 patients R-CHOP-like chemotherapy. Without rituximab group: 9 patients CHOD(8)-EDHAP, 3 MACOP-B and 3 CHOP. Overall 5-year survival for all patients treated was 83 %.