Examining ABO Compatible Donors in Double Lung Transplantation During the Era of Lung Allocation Score

Background. The short-term and long-term effect of using ABO compatible donors in the era of lung allocation score is unknown. This study determined if carefully selected ABO compatible donors could be used in double lung transplantation (DLT) with good outcomes. Methods. The United Network for Organ Sharing database was retrospectively reviewed for adult DLT from May 2005 to December 2011. Results. Of 6,655 double lung transplants, 493 (7.4%) were with ABO compatible donors and 6,162 (92.6%) were with ABO identical donors. In multivariate analysis, use of ABO compatible donors was not associated with mortality at 30 days (HR, 1.16; 95% CI, 0.76 to 1.79, p [ 0.49), 1 year (HR, 1.10; 95% CI, 0.86 to 1.42, p [ 0.46), and 5 years (HR, 1.06; 95% CI, 0.83 to 1.34, p [ 0.65). Variables associated with mortality at 5 years were donor female sex, donor age 60 years or greater, prolonged ischemic time, increasing recipient creatinine, recipient age, race mismatch, and mechanical ventilation or extracorporeal membrane oxygenation as a bridge to transplantation. Length of stay was longer in the ABOcompatiblegroup (30.9 vs 25.9 days, p [ 0.001). Acute rejection episodes on index hospitalization (8.8 vs. 8.9%, p [ 1.00), peak posttransplant forced expiratory volume in 1 second (FEV1) (82.7 vs 79.7%, p [ 0.053), and decrement in FEV1 over time were not different (p [ 0.13). Freedom from bronchiolitis obliterans syndrome was similar (1,475 vs 1,454 days, p [ 0.17). Conclusions. The use of ABO compatible donors in the era of lung allocation score was not associated with shortterm or long-term mortality and resulted in equivalent posttransplant lung function. A DLT with carefully selected ABO compatible donors can result in excellent outcomes.