Cardiovascular risk in peritoneal dialysis: a Portuguese multicenter study

205 205 http://www.revistanefrologia.com © 2014 Revista Nefrologia. Official Publication of the Spanish Nephrology Society originals Correspondence: Marta Neves Servicio de Nefrologia, Hospitais da Universidade de Coimbra. Praceta Professor Mota Pinto. 3000-075, Portugal. martaraq_neves@hotmail.com *Group formed: Helena Sa, Teresa Mendes, Anabela Rodrigues, Augusta Gaspar, Manuel Amoedo, Carla Araujo, Cristina Abreu, Joao Carlos Fernandes, Rui Castro, Ana Vila Lobos, Jose Assuncao, Ernesto Rocha, Carla Lima, Madalena Baptista, Idalecio Bernardo, Marilia Possante, Jose Sequeira Andrade, Jose Alves Teixeira. ABSTRACT Background: Cardiovascular (CV) disease is the major cause of mortality in patients undergoing renal replacement therapy. The primary aim of the study was to evaluate the CV risk profile and prevalence of CV disease in patients on peritoneal dialysis (PD) in Portugal. The secondary goal was to establish parameters most associated with CV disease. Methods: Retrospective, multicenter study of the preva - lent adult population on PD. Six hundred patients were in - cluded (56.7% male; mean age 53.5±15.3 years), on PD for 25.6±21.9 months. Patients were divided into two groups: group 1 (n=166) with CV disease and group 2 (n=434) with - out CV disease. Comparisons were made regarding tradi - tional CV risk factors and those associated with uremia and PD itself, and a multivariate analysis was performed to determine variables independently associated with CV disease. Results: At the end of the study, the prevalence of CV disease was 28%. At univariate analysis, group 1 presented a higher frequency of males ( P <.01), older pa - tients ( P <.01), diabetics ( P <.01), occurrence of left ventricu - lar hypertrophy (LVH) ( P <.01), mean C�reactive protein (CRP) ( P =.04), lower mean parathormone level ( P =.014), lower serum phosphorus ( P =.02), lower daily urine output ( P =.04), lower weekly Kt/V ( P =.008), increased use of ico - dextrin and hypertonic glucose-based PD solutions ( P <.001 and P =.006, respectively) and more were under continuous ambulatory PD (CAPD) ( P =.014) and had a high peritoneal transport status ( P =.02). Multivariate analysis provided a significant discriminatory influence pertaining to age >50 years, CRP>0.6mg/dl, male gender, diabetes, LVH, CAPD and anuria, when comparing group 1 and group 2. Conclu - sions: Risk factors most related to the development of CV disease in PD in Portugal are age >50 years, CRP>0.6mg/dL, male gender, diabetes, LVH, CAPD and anuria.