Chloropyramine increases NSCLC sensitivity to cisplatin in a SASH1 dependent manner

Introduction: SASH1 (SAM and SH3 domain-containing protein 1) is a putative tumor suppressor functioning in the control of apoptosis and cellular proliferation. Previously SASH1 has been shown to be down-regulated in approximately 90% of lung cancers, however little is known about the role of SASH1 in the pathogenesis of the disease. Our previously published data has shown that Chloropyramine a known competitive reversible H1-receptor antagonist, increases SASH1 protein level in breast cancer cells.