Expressions of androgen receptors in testicular and gubernaculum tissues in mice

Objective To investigate the expressions of androgen receptors (AR) in testicular and gubernaculum tissues in mice.Methods RNA and protein expressions of AR in testicular and tissues were studied by immtmohistochemistry and RT-PCR.Results AR mRNA was expressed in gubernaculum tissues of neonatal mouse.After birth,the expressions of AR in testis declined at first and then increased.In the group GD (gestation day) 17,GD19,PD (postnatal day,PD) 0,PD3 and PD7,the expression of AR in testes,were 39.49 ± 2.92、33.69 ± 3.46、41.21 ± 2.57、46.47 ± 4.68、55.73 ± 5.55 respectively.At the same time,the expression of AR in gubernaculum increased before birth and then declined.In the group GD17,GD19,PD0,PD3 and PD7,the expression of AR in gubemaculum,respectively,were 40.40 ± 4.08、46.77 ± 6.42、48.71 ± 3.71、45.06 ± 7.02、41.40 ±7.09.Conclusions AR is expressed in both the testis and gubernaculum tissue in neonatal mice,and they show corresponding changes with the aging of newborn mouse. Key words: Testis; Gubernaculum; Receptors,androgen