Malayenolides A-D, novel diterpenes from the indonesian sea pen veretillum malayense

Malayenolides A−D (1−4), four new briarane diterpenes, were isolated from the sea pen Veretillum malayense collected in Indonesia. The new diterpenes possess benzoate and senecioate substitutents, both of which are rare among marine natural products. The structures of the new compounds were determined from spectral data. Compounds 1−4 are toxic to brine shrimp.