Electrochemical studies of the interaction between famciclovir and BSA

In pH 7 BR buffer solution,using cyclic voltammetry and the differential pulse voltammetry at a glassy carbon electrode,the interaction between famciclovir and BSA were investigated.Compared to the sole famciclovir with the same concentration in the solution,the peak potential was unchangeable,the peak current reduced.This article discussed the influence of pH、 the reaction time、 scan rate、 accumulation time、 the quiet time on the interaction.A method for the concentration examination of bovine serum albumin was established,the proton and electron of electrochemical oxidation of famciclovir at the electrode is unchangeable,and the diffusion coefficient changed a little number,we guess that famciclovir maybe enter the hydrophobic water cavity of BSA,causing the decrease of the dissociative concentration.