Increased sperm count in 41 cases of idiopathic normogonadotropic oligozoospermia following treatment with tamoxifen

Clomiphene citrate has often been used in the treatment of idiopathic oligozoospermia. This anti-oestrogenic drug increases serum gonadotropins and testosterone, which in turn may stimulate spermatogenesis. However, evidence is lacking that clomiphene citrate clearly improves semen quality in oligozoospermic males1. This poor effect on oligozoospermia has been attributed to the intrinsic oestrogenic activity of clomiphene citrate, hence a less oestrogenic drug may be more suitable for treating such males.