Energetic dysfunction is mediated by mitochondrial ROS and precedes structural remodeling in metabolic heart disease

Ivan Luptak,Fuzhong Qin,Aaron L. Sverdlov,David R. Pimentel,Marcello Panagia,Dominique Croteau,Deborah A. Siwik,Markus M. Bachschmid,Huamei He,James A. Balschi,Wilson S. Colucci

Energetic dysfunction is mediated by mitochondrial ROS and precedes structural remodeling in metabolic heart disease

2019

Ivan Luptak
Fuzhong Qin
Aaron L. Sverdlov
David R. Pimentel
Marcello Panagia
Dominique Croteau
Deborah A. Siwik
Markus M. Bachschmid
Huamei He
James A. Balschi
Wilson S. Colucci

Aims: Metabolic syndrome is associated with metabolic heart disease (MHD) characterized by left ventricular (LV) hypertrophy, interstitial fibrosis, contractile dysfunction and mitochondrial dysfun...

Keywords:

Cell biology
Biology
Heart disease
Mitochondrial ROS
Endocrinology
Reactive oxygen species
Catalase
Mitochondrion
Internal medicine
Muscle hypertrophy
Metabolic syndrome
Metabolism
structural remodeling

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