Fast Tyrosinase Detection in Early Stage Melanoma with Nanomolar Sensitivity using Naphthalimide-based Fluorescent Read-out Probe

Naphthalimide-based red-emitting fluorescent read-out probes are developed for expeditious and sensitive detection of tyrosinase activity in live-cells. The probes show excellent photostability, pH-tolerance, specificity among several bio-analytes, non-toxic and extremely fast kinetics for tyrosinase detection with nanomolar sensitivity. The probe is also highly suitable for early melanoma detection.