Pituitary dysfunction types and clinical presentation of pituitary microadenomas in childhood and adolescence

• Three patients had precocious puberty, one male with beta subunit secreting microadenoma, and 2 females with non functioning pituitary micro adenomas. • Among two adolescents with normal stature and NFMA one have delayed puberty. Adolescent with prolonged gynecomastia was diagnosed, due to dynamic tests, as primary hypothyroid and with hyperprolactinaemia. • Also interesting results were found in 3 obese adolescent girls with secondary amenorrhea. • Although with normal basal hormonal status, they underwent meticulous dynamic investigation, because of presence of pituitary lesions, and we discovered primary hypothyroidism and hyperprolactinaemia in all of them. • Appropriate treatment led to shrinkage or complete radiological resolution of MAs.