SYNTHESIS AND CHARACTERIZATION OF A NEW STARCH ESTER WITH N-((N'-TIAZOLYL)-p'-(BENZENESULPHONE)) AMIDE OF N-(o- NITROBENZOYL)-D,L-ASPARAGIC ACID

The paper studies the dicyclohexylcarbodiimide-activated coupling reaction through ester-type covalent bonds of a sulfonamide derived from N-(m-nitrobenzoyl)-L-asparagic acid on starch. The amount of sulfonamide chemically-bonded to the support is dependent on the reaction parameters, the maximum coupling efficiency being attained at the highest values of the reaction parameters (DCC/sulfonamide molar ratio, sulfonamide/starch molar ratio and reaction time). The kinetics of drug release from the conjugates is studied under alkaline hydrolysis conditions. The conjugates present low toxicity and medium level antimicrobial activity against E. coli and S. aureus strains.