Cerium Oxide Nanoparticles are Nontoxic for Mouse Embryogenesis In Vitro and In Vivo

Cerium oxide nanoparticles (nanoceria) are considered as one of the most promising nanomaterials for biomedical applications. Complex analysis of cytotoxicity, including the assessment of effects on the reproductive system, is required for development of new biomedical materials. In this study, we investigated the effects of ultra-small citrate-stabilized cerium oxide nanoparticles on the development of mouse embryos in vitro and embryogenesis process in vivo. We have shown that nanoceria in a wide range of concentrations do not exert a toxic effect on the development of 2-cell embryos and embryogenesis.