Quinoline derivatives as diagnostic probes for tau protein accumulation diseases

Or a salt or solvate thereof tau protein is used as a probe for imaging diagnosis of diseases in which the accumulation, as well as compositions and kits containing the same. The method of dyeing neurofibrillary tangles in the brain material, as well as pharmaceutical compositions for prophylaxis and / or treatment of diseases β-sheet structure of the proteins are part of the etiology or pathogenesis provided.