In Vivo SPECT Imaging of Amyloid-β Deposition with Radioiodinated Imidazo[1,2-a]Pyridine Derivative DRM106 in a Mouse Model of Alzheimer's Disease

I-IMPY (2-(4′-dimethylaminophenyl)-6-iodo-imidazo[1,2-a]pyridine), a well-known amyloid SPECT ligand,by ex vivo autoradiographic analyses in 18-mo-old amyloid precur-sor protein transgenic mice. To verify the sensitivity and quantitationof radiolabeled DRM106 for in vivo imaging, we compared the de-tectability of Aβ plaques with