WOUND HEALING ACTIVITY OF GRACILARIA EDULIS (GMELIN) HYDRO ALCOHOLIC EXTRACT USING EXCISION AND DEAD CELL WOUND MODEL IN WISTAR RATS

Recently a lot of attentions have been drawn by the marine algae because it contain different bioactive compounds which are useful in the medicinal field. Gracilaria edulis (Gmelin) Linn belonging to family Rhodophytaceae various disease like cancer, acquired immune-deficiency syndrome (AIDS), inflammation, pain, arthritis, as well as viral, bacterial, and fungal infections. Their fore purpose of present study was to evaluate wound healing activity of Gracilaria edulis (Gmelin) extract against excision and dead space wound model on wistar rats. Both concentrations of hydro-alcoholic extracts showed significant response in both the wound type tested when compared with control group They were compared with vitamin E in the dead cell wound method and nitrofurazone in excision method. In both the model the HAE have shown significant activity compared to the standard. The excision methods have shown 92.12% at 200mg/kg and 97.89% at 400mg/kg concentrations. While the dead cell wound model have shown 63.83±0.7032 and 36.17±0.8333as wet weight and dry weight respectively at 200mg/kg and 41.67±0.6667 and 24.17±0.9458 weight of wet and dry weight respectively.