TCT-484 Immunologic Basis of Clopidogrel Hypersensitivity and Diagnosis by Lymphocyte Toxicity Assay

Clopidogrel hypersensitivity(HS)manifesting is a recognized complication affecting ∼3% of treated patients. Contrary to other drug allergy, the immunologic basis of clopidogrel HS are poorly understood. In this report, we characterize the cellular and immunologic mechanism of clopidogrel HS and