Can anti–oxidants prevent ischaemic heart disease?

SUMMARY Ischaemic heart disease remains a major cause of mortality in developed countries. A number of important risk factors for the development of coronary atherosclerosis have been identified including hypertension, hypercholesterolaemia, insulin resistance and smoking. However, these factors can only partly explain variations in the incidence of ischaemic heart disease either between populations or within populations over time. In addition, population interventions based upon these factors have had little impact in the primary prevention of heart disease. Recent evidence suggests that one of the important mechanisms predisposing to the development of atherosclerosis is oxidation of the cholesterol–rich low–density lipoprotein particle. This modification accelerates its uptake into macrophages, thereby leading to the formation of the cholesterol–laden ‘foam cell’. In vitro, low–density lipoprotein oxidation can be prevented by naturally occurring anti–oxidants such as vitamin C, vitamin E and beta–carotene. This article explores the evidence that these dietary anti–oxidants may influence the rate of progression of coronary atherosclerosis in vivo and discusses the need for formal clinical trials of anti–oxidant therapy.