Genome-wide loss-of-function genetic screening identifies opioid receptor |[mu]|1 as a key regulator of L-asparaginase resistance in pediatric acute lymphoblastic leukemia

S M Kang,Jesusa L. Rosales,V Meier-Stephenson,Sung-Woo Kim,Ki-Young Lee,A Narendran

Genome-wide loss-of-function genetic screening identifies opioid receptor |[mu]|1 as a key regulator of L-asparaginase resistance in pediatric acute lymphoblastic leukemia

2017

S M Kang
Jesusa L. Rosales
V Meier-Stephenson
Sung-Woo Kim
Ki-Young Lee
A Narendran

Genome-wide loss-of-function genetic screening identifies opioid receptor μ 1 as a key regulator of L-asparaginase resistance in pediatric acute lymphoblastic leukemia

Keywords:

Molecular oncology
Molecular biology
Cancer research
Cancer
Genome
Loss function
Opioid receptor
Biology
Regulator
Asparaginase
Growth factor receptor
Downregulation and upregulation
Programmed cell death
Gene knockdown
RNA interference
Apoptosis
Small hairpin RNA
Cell cycle

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