Centrobin controls mother–daughter centriole asymmetry in Drosophila neuroblasts

In Drosophila neuroblasts, Centrobin marks the daughter centriole, which, in contrast to the mother centriole, is able to retain pericentriolar material (PCM) and organize an interphase microtubule aster thought to guide the subsequent asymmetric division. Gonzalez and colleagues demonstrate that Centrobin is necessary and sufficient to mediate this centrosome asymmetry, that it binds centriole and PCM proteins, and is regulated by POLO kinase.