From urgency to frequency: facts and controversies of TRPs in the lower urinary tract

Members of transient receptor potential (TRP) superfamily are expressed in lower urinary tract (LUT) tissues, where they are mainly involved in nociception and mechanosensory transduction and represent potential targets for treating LUT disorders. In this Review, the authors discuss the evidence for a pivotal role of TRPV1, TRPV2, TRPV4, TRPM8, and TRPA1 in normal and pathological LUT function and consider the therapeutic strategies that might arise from targeting these channels.