[Synthesis and antibacterial activity of 7-(4-acylamino-thiocarbamoyl-1-piperazinyl) fluoroquinolone analogues in vitro].

Aim To synthesize new fluoroquinolone analogues as antibacterial compounds. Methods and Results By reaction of acryl chloride(chloro carbonic ester)with sodium sulfocyanate, acyl isosulfocyanic ester were easily obtained. Twelve 7 (4 acylamino thiocarbamoyl 1 piperazinyl)fluoroquinolone analogues (1-12) were synthesized through modifying the 7 piperazine of norflorxacin and ciprofloxacin with isosulfocyanic ester synthesized above. The structures of synthesized compounds were characterized by 1HNMR, IR and elemental analysis. Conclusion Antibacterial activities of the new compounds were evaluated in vitro compared with norflorxacin. Compounds 5,7,10 and 12 showed antibacterial activities.