[Clinical analysis of intraoperative radiotherapy in breast-conserving surgery of early breast cancer].

Objective To evaluate the safety and feasibility of intraoperative radiotherapy during breast-conserving surgery instead of whole breast radiotherapy in early breast cancer patients. Methods From July 2008 to December 2012, 36 early breast cancer patients underwent breast-conserving surgery plus interoperative radiotherapy on a Mobetron 1000 mobile electron accelerator.Postoperative recurrence and metastases, complications and cosmetic outcomes were recorded and analyzed. Results During a median follow-up period of 27.9 months, 2 patients (5.56%) underwent mastectomy after local relapses.There was no occurrence of distant metastasis or mortality.Their average wound healing time was 17 days and 2 of them (5.56%) developed infection while another 2 (5.56%) had delayed wound healing.And 1 patient (2.78%) showed wound edema and neither lyponecrosis nor hematoma was found.The evaluation of cosmetic outcome shows 32 patients (88.89%) were graded as excellent or good while another 4 (11.11%) fair or poor.None had radiotherapy-related acute hemotological toxicity and 2 patients (5.56%) developed skin pigmentation. Conclusion Intraoperative radiotherapy during breast-conserving surgery instead of whole breast radiotherapy in early breast cancer patients is both safe and reliable with better cosmetic outcomes. Key words: Breastneoplasms; Mammaplasty; Radiotherapy