Aerobic exercise training prevents renal damage in insulin resistance mice

Insulin resistance is associated with lipid accumulation in the kidney which leads to renal damage. We investigated the potential of aerobic exercise training (AET) to prevent renal damage in mice with diet-induced insulin resistance. Adult male C57BL6/J mice were assigned into chow-fed controls (C, n=7), cafeteria diet (CAF, n=7), chow-fed trained (T, n=7), and cafeteria diet plus trained (CAFT=7). The standard chow diet contained 4% of kilocalories from fat, 55% from carbohydrate and 22% from proteins (Nuvilab®, Parana, Brazil). The cafeteria diet contained 18.7% of kilocalories from fat, 56% from carbohydrate and 14.8% from proteins. PT was performed simultaneously with diet and consisted of 8-wk running session of 60 min at 60% of maximal speed, 5 days/wk. Experimental procedures were approved by Ethics Committee from Faculty of Medicine of University of Sao Paulo (#18/2014). Cafeteria diet induced insulin resistance in CAF group compared to C group during insulin tolerance test, which was counteracte...