A new hamster model for adenoviral vaccination

Both adult and baby hamsters infected intranasally with human adenovirus type 5 exhibited virologic, serologic, and histologic evidence of infection. When 8-day old hamsters were infected with 4×106 pfu, concentrations of virus up to 2×106 pfu/animal were detected in the lung, peaking on day 2. The minimum infectious dose was 1×103 pfu/animal. This model may be useful in studies of conventional and recombinant adenoviral vaccines for humans.